Study on phytochemical profile and anti-ulcerogenic effect of Cayratia pedatata Lam in albino wistar rats
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چکیده
The aim of this study is to evaluate the anti-ulcer activity of chloroform extract of leaves of Cayratia pedata (Lam). The chloroform extract of Cayratia pedata (CECP) was investigated for its anti-ulcer activity against pylorus ligation and ethanol induced gastric ulcers in rats. Ranitidine (50mg/kg,p.o.) and misoprostol (100ug/kg,p.o.) were used as standard drugs. A significant (p<0.01) anti-ulcer activity was observed in both the models. Both does of Cayratia pedata produced gastric anti-secretory effect in pylorus ligated rats and also showed gastric cytoprotective effect in ethanol induced gastric ulcers. Pylorus ligation showed significant (p<0.01) reduction in gastric volume. Free acidity, ulcer index as compared to control. It also showed significant (p<0.01) reduction in ulcer index in ethanol induced model with respect to control. This present study indicates that, Cayratia pedata leaves extract have potential anti-ulcer activity in this tested models.
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